The change in the relationship between the state and science is clearly manifested at the present time (we are talking about a slowdown in the growth of funding and a change in its principles, precarious employment in science, the prevalence of technoscience, etc.). After presenting the most characteristic features, the article discusses what these changes are related to and how objective they are. Based on the analysis of statistical data and strategic documents of a number of states, the reasons for the ongoing transformation are revealed. It is emphasized that its risks have been presented in many futuristic concepts representing scenarios for the development of society (from the knowledge society to transhumanism), but have not received due attention. It is concluded that we are witnessing a transition from the classical model of the relationship between science and the state, which emerged during the scientific and technological revolution of the twentieth century, to a new model characterized primarily by the expansion of the number of stakeholders, the creation of new forms of innovative research organization, networking and internationalization of scientific research, new techniques for evaluating and stimulating scientific activity, expertise of scientific projects, including public.